Osteophyte Bridge Formation Correlates with Vascular Calcification and Cardiovascular Disease in Diffuse Idiopathic Skeletal Hyperostosis

Diffuse idiopathic skeletal hyperostosis (DISH) is a noninflammatory spondyloarthropathy characterized by ectopic calcification of spinal cord tissue. Its etiology possibly polygenic. However, its pathogenesis and systemic effects remain unclear. Recent studies have reported high prevalence DISH in heart failure patients. The authors investigated how the incidence severity are associated with vascular occurrence cardiovascular events. In this retrospective chart review study, 500 patients disease who underwent surgery (cardiovascular events group) non-cardiovascular computed tomography scans (non-cardiovascular were randomly selected to investigate degree ossification anterior longitudinal ligament DISH. We found that was higher had more coronary arteries aorta. Next, we examined relationship between aortic calcification, DISH, event group. groups 31.4% 16.5%, respectively (p = 0.007). Aortic predominant certain level suggest some correlation This study important understanding pathophysiology